### What is the difference between HPMC K4M and K100M?
HPMC, or hydroxypropyl methylcellulose, is a commonly used pharmaceutical excipient in the form of different grades such as K4M and K100M. The main difference between HPMC K4M and K100M lies in their viscosity and molecular weight.
HPMC K4M has a lower viscosity and molecular weight compared to HPMC K100M. This means that K4M has a faster hydration rate and disintegration time in pharmaceutical formulations. It is commonly used in immediate-release tablets where rapid disintegration and drug release are required.
On the other hand, HPMC K100M has a higher viscosity and molecular weight, leading to slower hydration and disintegration rates. This makes K100M suitable for sustained-release formulations where a prolonged drug release profile is desired. It provides a controlled and steady release of the active pharmaceutical ingredient over an extended period of time.
In summary, the primary difference between HPMC K4M and K100M is their viscosity and molecular weight, which influence their hydration and disintegration properties in pharmaceutical formulations. K4M is used for immediate-release formulations with rapid drug release, while K100M is preferred for sustained-release formulations with controlled and prolonged drug release.
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